Pravastatin Sodium Tablets
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چکیده
Pravastatin sodium is available for oral administration as 10 mg, 20 mg, 40 mg, and 80 mg tablets. Inactive ingredients include: colloidal silicon dioxide, crospovidone, hydroxypropyl methylcellulose, magnesium stearate, mannitol, meglumine, microcrystalline cellulose and starch. The 10 mg, 20 mg and 80 mg tablets also contain D&C Yellow No 10 Aluminium Lake and the 40 mg tablet also contains D&C Yellow No 10 Aluminium Lake and FD&C Blue No. 1-Aluminium Lake.
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Pravastatin Sodium Tablets USP
10 mg, 20 mg, 40 mg & 80 mg Rx only DESCRIPTION Pravastatin sodium tablets are one of a class of lipid-lowering compounds, the HMG-CoA reductase inhibitors, which reduce cholesterol biosynthesis. These agents are competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme catalyzing the early rate-limiting step in cholesterol biosynthesis, conversion of HMG-C...
متن کاملBilateral pleural effusions associated with pravastatin sodium treatment.
Pravastatin sodium is a 3-hydroxyl-3-methylglutaryl-CoA reductase blocker used in the treatment of hypercholesterolaemia. We report on a patient who developed bilateral pleural effusions while he was being treated with the drug. The patient was a 60-yr-old male, a nonsmoker who was under treatment with 40 mg?day pravastatin since September 2005. He had no history of allergy or significant envir...
متن کاملReplacing lovastatin with pravastatin: effect on serum lipids and costs.
The effects on costs and lipid levels of replacing lovastatin therapy with pravastatin were studied. Beginning in April 1992, outpatients receiving lovastatin were switched to pravastatin. Physicians were asked but not required to initiate the pravastatin sodium treatment at half the daily lovastatin dose in milligrams. In October 1993, the dosages of lovastatin and pravastatin and the correspo...
متن کاملSimultaneous UV Spectrophotometric Determination of Pravastatin Sodium and Pioglitazone Hydrochloride in Pharmaceutical Preparations
Objectives: This study aimed to develop simple UV spectrophotometric methods for simultaneous determination of pravastatin sodium and pioglitazone hydrochloride without previous separation. Methods. The first method is the first derivative, where the peak amplitudes of first derivative of absorption spectra were measured at 249.7 and 277 nm for pravastatin sodium and pioglitazone hydrochloride ...
متن کاملQuantitative Determination of Pravastatin in Pharmaceutical Dosage Forms by High-Performance Liquid Chromatography with Ultraviolet Detection
A simple, sensitive and precise high-performance liquid chromatographic formulations assay for pravastatin (PVS) is described. Good chromatographic separation was achieved using a Teknokroma C8 (5 μm, 25cm × 4.6mm) column and a mobile phase consisting of 10mM ammonium acetate: methanol: triethylamine (40:60:0.17 v/v/v) while at a flow-rate of 1.0 mL min(-1). PVS was detected at 239 nm and was e...
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